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Non-Malignant Respiratory Disease Among Workers in Industries Using Styrene—A Review of the Evidence
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2 2017
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Source: Am J Ind Med. 60(2):163-180
[PDF-440.38 KB]
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Journal Article:Am J Ind Med
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Description:Background
Asthma and obliterative bronchiolitis (OB) cases have occurred among styrene-exposed workers. We aimed to investigate styrene as a risk factor for non-malignant respiratory disease (NMRD).
Methods
From a literature review, we identified case reports and assessed cross-sectional and mortality studies for strength of evidence of positive association (i.e., strong, intermediate, suggestive, none) between styrene exposure and NMRD-related morbidity and mortality.
Results
We analyzed 55 articles and two unpublished case reports. Ten OB cases and eight asthma cases were identified. Six (75%) asthma cases had abnormal styrene inhalation challenges. Thirteen (87%) of 15 cross-sectional studies and 12 (50%) of 24 mortality studies provided at least suggestive evidence that styrene was associated with NMRD-related morbidity or mortality. Six (66%) of nine mortality studies assessing chronic obstructive pulmonary disease-related mortality indicated excess mortality.
Conclusions
Available evidence suggests styrene exposure is a potential risk factor for NMRD. Additional studies of styrene-exposed workers are warranted.
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Pubmed ID:28079275
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Pubmed Central ID:PMC5379121
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Volume:60
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Issue:2
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