Heterologous protection against Crimean-Congo hemorrhagic fever in mice after a single dose of replicon particle vaccine

Spengler, Jessica R.; Welch, Stephen R.; Scholte, Florine E.M.; Coleman-McCray, JoAnn D.; Harmon, Jessica R.; Nichol, Stuart T.; Bergeron, Éric; Spiropoulou, Christina F.

doi:10.1016/j.antiviral.2019.104573

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Heterologous protection against Crimean-Congo hemorrhagic fever in mice after a single dose of replicon particle vaccine

10 2019
By Spengler, Jessica R. ; Welch, Stephen R. ; Scholte, Florine E.M. ; ...
http://dx.doi.org/10.1016/j.antiviral.2019.104573
Source: Antiviral Res. 170:104573

[PDF-1.13 MB]

English

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Details:

Alternative Title:

Antiviral Res
Personal Author:

Spengler, Jessica R. ; Welch, Stephen R. ; Scholte, Florine E.M. ; Coleman-McCray, JoAnn D. ; Harmon, Jessica R. ; ... More +

Spengler, Jessica R. ; Welch, Stephen R. ; Scholte, Florine E.M. ; Coleman-McCray, JoAnn D. ; Harmon, Jessica R. ; Nichol, Stuart T. ; Bergeron, Éric ; Spiropoulou, Christina F. Less -
Description:

No vaccines are currently licensed to prevent Crimean-Congo hemorrhagic fever virus (CCHFV) infection, which can cause mild self-limiting clinical signs or severe, often fatal hemorrhagic fever disease. Here we continued investigations into the utility of a single-dose virus replicon particle (VRP) vaccine regimen by assessing protection against Turkey or Oman strains of CCHFV. We found that all mice were completely protected from disease, supporting broad applicability of this platform for CCHFV prevention.
Keywords:

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Animals Antibodies, Neutralizing Antibodies, Viral Crimean-Congo Hemorrhagic Fever Disease Disease Models, Animal Female Hemorrhagic Fever Hemorrhagic Fever, Crimean Hemorrhagic Fever Virus, Crimean-Congo Heterologous Protection IFNAR−/− Mice Immunity, Heterologous Mice Replicon Replicon Particle Vaccine Viral Vaccines Virion Virus VRP
Source:

Antiviral Res. 170:104573
Pubmed ID:

31377243
Pubmed Central ID:

PMC6773275
Document Type:

Journal Article
Funding:

CC999999/ImCDC/Intramural CDC HHSUnited States/ ; R01 AI109008/AI/NIAID NIH HHSUnited States/

CC999999/ImCDC/Intramural CDC HHSUnited States/ ; R01 AI109008/AI/NIAID NIH HHSUnited States/ Less -
Volume:

170
Collection(s):

CDC Public Access
Main Document Checksum:

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urn:sha256:63bcf8aaf6d35f1137880b2e67ce59de09e26e14f7d34262eded4f2a84758dd0
Download URL:

https://stacks.cdc.gov/view/cdc/94463/cdc_94463_DS1.pdf
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