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Incidence of Hepatocellular Carcinoma among Older Americans Attributable to Hepatitis C and Hepatitis B, 2001-2013
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8 01 2019
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Source: Cancer. 125(15):2621-2630
[PDF-527.88 KB]
Details:
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Alternative Title:Cancer
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Personal Author:
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Description:Background:
In the United States, incidence and mortality rates of hepatocellular carcinoma (HCC) are increasing in older individuals. Chronic infection with hepatitis C virus (HCV) and hepatitis B virus (HBV) are important causes of HCC; however, the contribution of viral hepatitis to recent trends in HCC incidence among older Americans is unclear.
Methods:
We used data from the Surveillance, Epidemiology and End Results-Medicare linkage (SEER-Medicare) for years 2001–2013 to identify HCC cases among individuals aged ≥66 years and Medicare files to assess the HCV and HBV status of HCC cases. Age-standardized incidence rates of HCV-attributable, HBV-attributable and HCV/HBV-unrelated HCC were estimated overall, and by age group, sex, and race/ethnicity. We also calculated annual percent changes (APCs) in HCC incidence.
Results:
During 2001–2013, 15,300 HCC cases occurred in this population. Overall HCC rates increased 43% from 16.3 to 23.3/100,000 (APC=3.40%/year), while HCV-attributable HCC rates almost doubled from 4.2 to 8.2/100,000 (APC=5.62%/year). HCC rates increased more slowly for HBV-attributable HCC (1.3 to 1.8/100,000; APC=3.17%/year) and HCV/HBV-unrelated HCC (11.3 to 14.1/100,000, APC=2.35%/year). The proportion of HCC cases with evidence of HCV infection increased from 25.7% in 2001–2004 to 32.3% in 2011–2013, while the proportion with HBV remained stable at 8%. In 2013, higher rates for both HCV- and HBV-attributable HCC were seen in individuals ages 66–75 years, men and individuals of Asian ancestry.
Conclusions:
Among Americans aged ≥66 years, HCC rates increased rapidly during 2001–2013. HCV-attributable cases contributed substantially to this increase, however, rates of HBV-attributable and HCV/HBV-unrelated HCC also rose during this period.
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Source:
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Pubmed ID:30980394
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Pubmed Central ID:PMC6625871
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Volume:125
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Issue:15
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