Lassa Virus Replicon Particle Vaccine Protects Strain 13/N Guinea Pigs Against Challenge With Geographically and Genetically Diverse Viral Strains

Spengler, Jessica R.; Kainulainen, Markus H.; Welch, Stephen R.; Coleman-McCray, JoAnn D.; Harmon, Jessica R.; Condrey, Jillian A.; Scholte, Florine E. M.; Nichol, Stuart T.; Montgomery, Joel M.; Albariño, César G.; Spiropoulou, Christina F.

doi:10.1093/infdis/jiac028

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Lassa Virus Replicon Particle Vaccine Protects Strain 13/N Guinea Pigs Against Challenge With Geographically and Genetically Diverse Viral Strains

11 01 2022
By Spengler, Jessica R. ; Kainulainen, Markus H. ; Welch, Stephen R. ; ...
http://dx.doi.org/10.1093/infdis/jiac028
Source: J Infect Dis. 226(9):1545-1550

[PDF-1.40 MB]

English

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Details:

Alternative Title:

J Infect Dis
Personal Author:

Spengler, Jessica R. ; Kainulainen, Markus H. ; Welch, Stephen R. ; Coleman-McCray, JoAnn D. ; Harmon, Jessica R. ; ... More +

Spengler, Jessica R. ; Kainulainen, Markus H. ; Welch, Stephen R. ; Coleman-McCray, JoAnn D. ; Harmon, Jessica R. ; Condrey, Jillian A. ; Scholte, Florine E. M. ; Nichol, Stuart T. ; Montgomery, Joel M. ; Albariño, César G. ; Spiropoulou, Christina F. Less -
Description:

Lassa virus (LASV) causes mild to severe hemorrhagic fever disease in humans. Strain 13/N guinea pigs are highly susceptible to infection with LASV strain Josiah (clade IV), providing a critical model system for therapeutics and vaccine development. To develop additional models of disease, we detail the clinical course in guinea pigs infected with 5 geographically and genetically diverse LASV strains. Two of the developed models (LASV clades II and III) were then used to evaluate efficacy of a virus replicon particle vaccine against heterologous LASV challenge, demonstrating complete protection against clinical disease after a single vaccination dose.
Subjects:

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Animals Guinea Pigs Humans Lassa Fever Lassa Virus Replicon Vaccination Viral Vaccines
Keywords:

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Animal Model Disease Hemorrhagic Fever Lassa Fever Protection Strain 13/N Guinea Pigs Vaccine Viral Replicon Particle Virus
Source:

J Infect Dis. 226(9):1545-1550
Pubmed ID:

35099012
Pubmed Central ID:

PMC11268724
Document Type:

Journal Article
Funding:

CC999999/ImCDC/Intramural CDC HHSUnited States/ ; CC/CDC HHSUnited States/

CC999999/ImCDC/Intramural CDC HHSUnited States/ ; CC/CDC HHSUnited States/ Less -
Volume:

226
Issue:

9
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha-512:f55ae354caf604eb17f1270901c8ac54c87f802a87d2cb34637f5baae6abea515a0a36303720b7ebd482f696c54e89c0f08dfebeb25cdf4df90490cb1158e5f7
Download URL:

https://stacks.cdc.gov/view/cdc/159403/cdc_159403_DS1.pdf
File Type:

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	NIHMS1983292-supplement-1.pdf	pdf

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