Factors associated with Humoral Immune Response in Older Adults who Received Egg-free Influenza Vaccine

Williams, Katherine V.; Geffel, Krissy Moehling; Alcorn, John F.; Nowalk, Mary Patricia; Levine, Min Z.; Kim, Sara S.; Flannery, Brendan; Susick, Michael; Zimmerman, Richard K.

doi:10.1016/j.vaccine.2022.12.041

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Factors associated with Humoral Immune Response in Older Adults who Received Egg-free Influenza Vaccine

1 16 2023
By Williams, Katherine V. ; Geffel, Krissy Moehling ; Alcorn, John F. ; ...
http://dx.doi.org/10.1016/j.vaccine.2022.12.041
Source: Vaccine. 41(3):862-869

[PDF-119.81 KB]

English

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Details:

Alternative Title:

Vaccine
Personal Author:

Williams, Katherine V. ; Geffel, Krissy Moehling ; Alcorn, John F. ; Nowalk, Mary Patricia ; Levine, Min Z. ; ... More +

Williams, Katherine V. ; Geffel, Krissy Moehling ; Alcorn, John F. ; Nowalk, Mary Patricia ; Levine, Min Z. ; Kim, Sara S. ; Flannery, Brendan ; Susick, Michael ; Zimmerman, Richard K. Less -
Description:

Background:

Immune responses to influenza vaccination tend to be lower among older, frequently vaccinated adults. Use of egg-free influenza vaccines is increasing, but limited data exist on factors associated with their immunogenicity in older adults.

Methods:

Community-dwelling older adults ≥56 years of age were enrolled in a prospective, observational study of immunogenicity of 2018–2019 influenza vaccine. Hemagglutination inhibition (HAI) antibody titers were measured pre-vaccination (Day 0) and four weeks after vaccination (Day 28) to calculate geometric mean titers, seropositivity (HAI titers ≥1:40), seroconversion (four-fold rise in HAI titer with post-vaccination titer ≥1:40) and geometric mean fold rise (GMFR). Linear regression models assessed the association of predictors of GMFR for each vaccine antigen.

Results:

Among 91 participants who received egg-free influenza vaccines, 84 (92.3%) received quadrivalent recombinant influenza vaccine (RIV4, Flublok, Sanofi Pasteur), and 7 (7.7%) received quadrivalent cell culture-based influenza vaccine (ccIIV4, Flucelvax, Seqirus). Pre-vaccination seropositivity was 52.8% for A(H1N1), 94.5% for A(H3N2), 61.5% for B/Colorado and 48.4% for B/Phuket. Seroconversion by antigen ranged from 16.5% for A(H1N1) and B/Colorado to 37.4% for A(H3N2); 40 participants failed to seroconvert to any antigen. Factors independently associated with higher GMFR in multivariable models included lower pre-vaccination HAI antibody titer for A(H1N1), B/Colorado and B/Phuket, and younger age for A(H1N1).

Conclusion:

Overall pre-vaccination seropositivity was high and just over half of the cohort seroconverted to ≥1 vaccine antigen. Antibody responses were highest among participants with lower pre-vaccination titers. Among older adults with high pre-existing antibody titers, approaches to improve immune responses are needed.
Keywords:

[+]

Adults Aged Antibodies, Viral Egg-free Influenza Vaccine Hemagglutination Inhibition Assay Hemagglutination Inhibition Tests Humans Humoral Response Immunity, Humoral Influenza Influenza, Human Influenza A Virus, H1N1 Subtype Influenza A Virus, H3N2 Subtype Influenza Vaccines Prospective Studies Vaccines, Combined Vaccines, Inactivated
Source:

Vaccine. 41(3):862-869
Pubmed ID:

36543682
Pubmed Central ID:

PMC9850444
Document Type:

Journal Article
Funding:

U01 IP001035/IP/NCIRD CDC HHSUnited States/ ; U01IP001035/ACL/ACL HHSUnited States/ ; UL1 TR001857/TR/NCATS NIH HHSUnited States/

U01 IP001035/IP/NCIRD CDC HHSUnited States/ ; U01IP001035/ACL/ACL HHSUnited States/ ; UL1 TR001857/TR/NCATS NIH HHSUnited States/ Less -
Volume:

41
Issue:

3
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:6f5b74636fc97053d0c0497958ff9a8866da10050c315021ba225fe6d390615f
Download URL:

https://stacks.cdc.gov/view/cdc/123833/cdc_123833_DS1.pdf
File Type:

	nihms-1859612.nxml	xml
	NIHMS1859612-supplement-1.docx	docx
	NIHMS1859612-supplement-2.docx	docx

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