First Trimester Plasma Glucose Values in Non-Diabetic Women are Associated with Risk for Congenital Heart Disease in Offspring

Helle, Emmi I.T.; Biegley, Preston; Knowles, Joshua W.; Leader, Joseph B.; Pendergrass, Sarah; Yang, Wei; Reaven, Gerald R; Shaw, Gary M.; Ritchie, Marylyn; Priest, James R.

doi:10.1016/j.jpeds.2017.10.046

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First Trimester Plasma Glucose Values in Non-Diabetic Women are Associated with Risk for Congenital Heart Disease in Offspring

4 2018
By Helle, Emmi I.T. ; Biegley, Preston ; Knowles, Joshua W. ; ...
http://dx.doi.org/10.1016/j.jpeds.2017.10.046
Source: J Pediatr. 195:275-278

[PDF-53.00 KB]

English

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Details:

Alternative Title:

J Pediatr
Personal Author:

Helle, Emmi I.T. ; Biegley, Preston ; Knowles, Joshua W. ; Leader, Joseph B. ; Pendergrass, Sarah ; ... More +

Helle, Emmi I.T. ; Biegley, Preston ; Knowles, Joshua W. ; Leader, Joseph B. ; Pendergrass, Sarah ; Yang, Wei ; Reaven, Gerald R ; Shaw, Gary M. ; Ritchie, Marylyn ; Priest, James R. Less -
Description:

In a retrospective study of 19 171 mother-child dyads, elevated random plasma glucose values during early pregnancy were directly correlated with increased risk for congenital heart disease in offspring. Plasma glucose levels proximal to the period of cardiac development may represent a modifiable risk factor for congenital heart disease in expectant mothers without diabetes.
Subjects:

[+]

Adolescent Adult Biomarkers Blood Glucose Female Heart Defects, Congenital Humans Hyperglycemia Infant, Newborn Pregnancy Pregnancy Complications Pregnancy Trimester, First Retrospective Studies Risk Factors Young Adult
Keywords:

[+]

Congenital Heart Disease Congenital Malformation Diabetes Oral Glucose Tolerance Test Plasma Glucose
Source:

J Pediatr. 195:275-278
Pubmed ID:

29254757
Pubmed Central ID:

PMC5869072
Document Type:

Journal Article
Funding:

2016097/DDCF/Doris Duke Charitable FoundationUnited States/ ; U01 DD001033/DD/NCBDD CDC HHSUnited States/ ; U01DD001033/ACL/ACL HHSUnited States/ ; P30 DK116074/DK/NIDDK NIH HHSUnited States/ ; K99 HL130523/HL/NHLBI NIH HHSUnited States/ ; ... More +

2016097/DDCF/Doris Duke Charitable FoundationUnited States/ ; U01 DD001033/DD/NCBDD CDC HHSUnited States/ ; U01DD001033/ACL/ACL HHSUnited States/ ; P30 DK116074/DK/NIDDK NIH HHSUnited States/ ; K99 HL130523/HL/NHLBI NIH HHSUnited States/ ; R00 HL130523/HL/NHLBI NIH HHSUnited States/ Less -
Volume:

195
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:427cf59fa18865d52775eddbdc118bef903ad8df8c0ffb6bb668a55b76c62b2f
Download URL:

https://stacks.cdc.gov/view/cdc/52940/cdc_52940_DS1.pdf
File Type:

nihms914568.nxml

xml

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