Details:

• Alternative Title:
  J Acquir Immune Defic Syndr
• Personal Author:
  Hanh, Ngo Thi Hong ; Tram, Pham Thi Phuong ; Ha, Hoang Thi Thanh ; Duc, Bui Hoang ; Huong, Phan Thi Thu ; ... More +

  Hanh, Ngo Thi Hong ; Tram, Pham Thi Phuong ; Ha, Hoang Thi Thanh ; Duc, Bui Hoang ; Huong, Phan Thi Thu ; Quoc, Nguyen Cuong ; Thanh, Duong Cong ; Hien, Bui Thu ; Ha, Nguyen Thi Thanh ; Mai, Le Thi Quynh ; Anh, Dang Duc ; McFarland, Willi ; Hong-Ha, Truong M. ; Thang, Pham Hong Less -
• Description:
  Background:
  
  HIV drug resistance (HIVDR) can reduce the effectiveness of antiretroviral (ARV) drugs in preventing morbidity and mortality, limit options for treatment, and prevention. Our study aimed to assess HIV-1 subtypes and HIVDR among key populations in HIV Sentinel Surveillance Plus Behavior (HSS+) in 2018 and 2020.
  
  Methods:
  
  One-stage venue-based cluster sampling was used to recruit participants at hotspots identified for Men who have sex with men (MSM) in 7 provinces and SEM females and female sex worker (FSW) in 13 provinces. Participants completed a standard questionnaire about risk and preventive behaviors, and ART history, and provided intravenous blood for HIV testing. HIVDR testing was conducted on HIV-positive samples with VL >1,000 copies/ml.
  
  Results:
  
  A total of 185/435 (42.5%) HIV-positive samples had viral load ≥1,000 copies/ml, of which 130/136 from MSM and 26/49 from FSW, were successfully sequenced. Six HIV-1 subtypes were detected (CRF01_AE, A, CRF07/08_BC, B, C, CRF25_cpx), with CRF01_AE (82.7%, 129/156) the most common. Drug resistance mutations were detected in 16.7% of participants overall (26/156), in 15.4% (20/130) of MSM, and in 23.1% (6/26) of FSW. Mutations associated with resistance to NNRTI were the most frequently detected (73.1%, 19/26). The high level of resistance was presented in NNRTI and NRTI classes. There are 10 major resistance mutations detected with NRTI (M184VI-25.0%, K65KR-50.0%, Y115F-25%), NNRTI (K103N-21.1%, E138A-10.5%, V106M-5.3%, K101E-5.3%, G190A-5.3%) PI (L33F-40.0%, M46L-20.0%).
  
  Conclusions:
  
  Vietnam’s HSS+ system identified an emerging strain of HIV-1 and mutations associated with resistance to multiple drug classes among MSM and FSW.
  
  
• Subjects:
  [+]

  Adolescent Adult Anti-HIV Agents Drug Resistance, Viral Female HIV-1 HIV Infections Homosexuality, Male Humans Male Middle Aged Mutation Sentinel Surveillance Sex Workers Vietnam Viral Load Young Adult
• Keywords:
  [+]

  Antiretroviral Therapy Drug Resistance Men Who Have Sex With Men Sex Workers
• Source:
  J Acquir Immune Defic Syndr. 98(1):29-36
• Pubmed ID:
  39322986
• Pubmed Central ID:
  PMC11624091
• Document Type:
  Journal Article
• Funding:
  U2G GH001016/GH/CGH CDC HHSUnited States/ ; GH001016/U.S. President's Emergency Plan for AIDS Relief/

  U2G GH001016/GH/CGH CDC HHSUnited States/ ; GH001016/U.S. President's Emergency Plan for AIDS Relief/ Less -
• Volume:
  98
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  [+]

  urn:sha-512:e61e8eba739954cfb5ba4751da45432be2f0a55ffb47c621699685fb487e9f6c20aa186930610f1c100ec7a16f606d2e1a60cd05fb2bcfaa193041ffe4046136
• File Type:

• Supporting Files:
  No Additional Files