Newly Recognized Spotted Fever Group Rickettsia as Cause of Severe Rocky Mountain Spotted Fever–Like Illness, Northern California, USA

Probert, Will S.; Haw, Monica P.; Nichol, Aran C.; Glaser, Carol A.; Park, Sarah Y.; Campbell, Laura E.; Trivedi, Kavita K.; Romo, Hannah; Saunders, Megan E.M.; Kjemtrup, Anne M.; Padgett, Kerry A.; Hacker, Jill K.

doi:10.3201/eid3007.231771

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Newly Recognized Spotted Fever Group Rickettsia as Cause of Severe Rocky Mountain Spotted Fever–Like Illness, Northern California, USA

7 2024
By Probert, Will S. ; Haw, Monica P. ; Nichol, Aran C. ; ...
http://dx.doi.org/10.3201/eid3007.231771
Source: Emerg Infect Dis. 2024; 30(7):1344-1351

[PDF-676.10 KB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Probert, Will S. ; Haw, Monica P. ; Nichol, Aran C. ; Glaser, Carol A. ; Park, Sarah Y. ; ... More +

Probert, Will S. ; Haw, Monica P. ; Nichol, Aran C. ; Glaser, Carol A. ; Park, Sarah Y. ; Campbell, Laura E. ; Trivedi, Kavita K. ; Romo, Hannah ; Saunders, Megan E.M. ; Kjemtrup, Anne M. ; Padgett, Kerry A. ; Hacker, Jill K. Less -
Description:

The incidence of spotted fever group (SFG) rickettsioses in the United States has tripled since 2010. Rocky Mountain spotted fever, the most severe SFG rickettsiosis, is caused by Rickettsia rickettsii. The lack of species-specific confirmatory testing obfuscates the relative contribution of R. rickettsii and other SFG Rickettsia to this increase. We report a newly recognized rickettsial pathogen, Rickettsia sp. CA6269, as the cause of severe Rocky Mountain spotted fever-like illness in 2 case-patients residing in northern California. Multilocus sequence typing supported the recognition of this pathogen as a novel Rickettsia genotype most closely related to R. rickettsii. Cross-reactivity observed for an established molecular diagnostic test indicated that Rickettsia sp. CA6269 might be misidentified as R. rickettsii. We developed a Rickettsia sp. CA6269-specific real-time PCR to help resolve this diagnostic challenge and better characterize the spectrum of clinical disease and ecologic epidemiology of this pathogen.
Subjects:

[+]

Adult Female Male Middle Aged Multilocus Sequence Typing Phylogeny Rickettsia Rickettsia Rickettsii Rocky Mountain Spotted Fever Spotted Fever Group Rickettsiosis
Keywords:

[+]

Antimicrobial Resistance Bacteria California Germ Theory Infectious Diseases Multilocus Sequence Typing Public Health Public Health History Real-time PCR Rickettsiosis Rocky Mountain Spotted Fever Science Pioneers Spotted Fever Group Rickettsia Ticks United States Vector-borne Infections
Source:

Emerg Infect Dis. 2024; 30(7):1344-1351
Pubmed ID:

38816345
Pubmed Central ID:

PMC11210658
Document Type:

Journal Article
Place as Subject:

California
Volume:

30
Issue:

7
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:a5960d16f13e97750b323848d19a97f8552bbf2addf89b3ee9f97f2d67fb8e5e
Download URL:

https://stacks.cdc.gov/view/cdc/158103/cdc_158103_DS1.pdf
File Type:

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	23-1771-F.jpg	jpeg
	23-1771-Techapp-s1.pdf	pdf
	23-1771.nxml	xml

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