Characteristics of TB cases without documented sputum culture in the United States, 2011–2021

Rautman, L.H.; Kammerer, J.S.; Silk, B.J.; Marconi, V.C.; Youngblood, M.E.; Edwards, J.A.; Wortham, J.M.; Self, J.L.

doi:10.5588/ijtld.23.0432

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Characteristics of TB cases without documented sputum culture in the United States, 2011–2021

5 01 2024
By Rautman, L.H. ; Kammerer, J.S. ; Silk, B.J. ; ...
Source: Int J Tuberc Lung Dis. 28(5):231-236

Public Access Version Available on: May 01, 2025, 12:00 AM

Please check back on the date listed above.

English

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Details:

Alternative Title:

Int J Tuberc Lung Dis
Personal Author:

Rautman, L.H. ; Kammerer, J.S. ; Silk, B.J. ; Marconi, V.C. ; Youngblood, M.E. ; ... More +

Rautman, L.H. ; Kammerer, J.S. ; Silk, B.J. ; Marconi, V.C. ; Youngblood, M.E. ; Edwards, J.A. ; Wortham, J.M. ; Self, J.L. Less -
Description:

BACKGROUND:

Culture-based diagnostics are the gold standard for diagnosing pulmonary TB (PTB). We characterized culture practices by comparing cases with documented sputum culture to those without.

METHODS:

Using multivariable logistic regression, we examined associations between PTB case characteristics and no documented sputum culture reported to the U.S. National TB Surveillance System during 2011–2021.

RESULTS:

Among 69,538 PTB cases analyzed, no sputum culture attempt was documented for 5,869 (8%). Non-sputum culture specimens were documented for 54%, 80%, and 89% of cases without documented sputum culture attempts among persons aged <15 years, 15–64, and 65+ years, respectively; bronchial fluid and lung tissue were common non-sputum specimens among cases in persons >15 years old. Having no documented sputum culture was associated with age <15 years (aOR 23.84, 99% CI 20.09–28.27) or ≥65 years (aOR 1.22, 99% CI 1.07–1.39), culture of a non-sputum specimen (aOR 6.57, 99% CI 5.93–7.28), residence in a long-term care facility (aOR 1.58, 99% CI 1.23–2.01), and receiving TB care outside of a health department (aOR 1.79, 99% CI 1.61–1.98).

CONCLUSIONS:

Inability to obtain sputum from children and higher diagnostic suspicion for disease processes that require tissue-based diagnostics could explain these findings.
Subjects:

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Adolescent Adult Aged Child Child, Preschool Female Humans Infant Logistic Models Male Middle Aged Mycobacterium Tuberculosis Sputum Tuberculosis, Pulmonary Young Adult
Keywords:

[+]

Long-term Care TB Diagnostics
Source:

Int J Tuberc Lung Dis. 28(5):231-236
Pubmed ID:

38659143
Pubmed Central ID:

PMC11103590
Document Type:

Journal Article
Funding:

CC999999/ImCDC/Intramural CDC HHSUnited States/ ; P30 AI050409/AI/NIAID NIH HHSUnited States/

CC999999/ImCDC/Intramural CDC HHSUnited States/ ; P30 AI050409/AI/NIAID NIH HHSUnited States/ Less -
Place as Subject:

United States
Volume:

28
Issue:

5
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha-512:996db6bd37d7e0ed56bb7a359bc61f6d83a14a608ea9116b2cfd5a20ff261246e92fc705ca15826f4f952fc40f530be0dafa8fbee39072218b1f4e5f7ad0736b
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