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Population-based Prevalence and Incidence Estimates of Mixed Connective Tissue Disease from the Manhattan Lupus Surveillance Program
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8 01 2023
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Source: Rheumatology (Oxford). 62(8):2845-2849
[PDF-73.55 KB]
Details:
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Alternative Title:Rheumatology (Oxford)
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Personal Author:
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Description:Objective:
Epidemiologic data for mixed connective tissue disease (MCTD) are limited. Leveraging data from the Manhattan Lupus Surveillance Program (MLSP), a racially/ethnically diverse population-based registry of cases with SLE and related diseases including MCTD, we provide estimates of the prevalence and incidence of MCTD.
Methods:
MLSP cases were identified from rheumatologists, hospitals, and population databases using a variety of ICD-9 codes. MCTD was defined as one of the following: 1) fulfillment of our modified Alarcon-Segovia and Kahn criteria which required a positive RNP antibody and the presence of synovitis, myositis, and Raynaud’s phenomenon, 2) a diagnosis of MCTD and no other diagnosis of another connective tissue disease (CTD), and 3) a diagnosis of MCTD regardless of another CTD diagnosis.
Results:
Overall, 258 (7.7%) of cases met a definition of MCTD. Using our modified Alarcon-Segovia and Kahn criteria for MCTD, the age-adjusted prevalence was 1.28 (95%CI 0.72-2.09) per 100,000. Using our definition of a diagnosis of MCTD and no other diagnosis of another CTD yielded an age-adjusted prevalence and incidence of MCTD of 2.98 (95%CI 2.10-4.11) per 100,000 and 0.39 (95%CI 0.22-0.64) per 100,000, respectively. The age-adjusted prevalence and incidence were highest using a diagnosis of MCTD regardless of other CTD diagnoses and were 16.22 (95%CI 14.00-18.43) per 100,000 and 1.90 (95%CI 1.49-2.39) per 100,000 respectively.
Conclusions:
The MLSP provided estimates for prevalence and incidence of MCTD in a diverse population. The variation in estimates using different case definitions is reflective of the challenge of defining MCTD in epidemiologic studies.
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Pubmed ID:36538873
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Pubmed Central ID:PMC11068036
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Funding:
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Volume:62
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Issue:8
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