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Investigation of donor-derived Strongyloides stercoralis infection in multiple solid organ transplant recipients—California, Michigan, Ohio, 2022
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6 2023
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Source: Transpl Infect Dis. 25(3):e14059
[PDF-58.73 KB]
Details:
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Alternative Title:Transpl Infect Dis
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Description:Background:
The Centers for Disease Control and Prevention led an investigation to determine if Strongyloides infection in a right kidney recipient was an existing chronic infection, or if the infection was transmitted from an infected organ donor.
Methods:
Evidence regarding the organ donor and organ recipients Strongyloides testing, treatment, and risk factors were gathered and evaluated. The case classification algorithm created by the Disease Transmission Advisory Committee was utilized.
Results:
The organ donor had risk factors for Strongyloides infection; the banked donor specimen, submitted for serology testing 112 days post-donor death, was positive. The right kidney recipient was negative for Strongyloides infection pretransplant. Strongyloides infection was diagnosed via small bowel and stomach biopsies. The left kidney recipient had risk factors for Strongyloides infection. Two posttransplant Strongyloides antibody tests were negative at 59 and 116 days posttransplant; repeat antibody tests returned positive at 158 and 190 days posttransplant.
Conclusion:
The results of this investigation support the importance of preventing donor-derived Strongyloides infections by laboratory-based serology testing of solid organ donors. Donor positive testing results would direct the monitoring and treatment of recipients to avoid severe complications.
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Pubmed ID:37005911
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Pubmed Central ID:PMC10921863
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Funding:
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Volume:25
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Issue:3
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