CDC Laboratory Recommendations for Syphilis Testing, United States, 2024

Papp, John R.; Park, Ina U.; Fakile, Yetunde; Pereira, Lara; Pillay, Allan; Bolan, Gail A.

doi:10.15585/mmwr.rr7301a1

Advanced Search

Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.

Search our Collections & Repository

Advanced Search
Custom Query

All these words:

For very narrow results

This exact word or phrase:

When looking for a specific result

Any of these words:

Best used for discovery & interchangable words

None of these words:

Recommended to be used in conjunction with other fields

Language:

Dates

Publication Date Range:

to

Document Data

Title:

Document Type:

Library

Collection:

Series:

People

Author:

Clear All

Query Builder

Query box

Clear All

For additional assistance using the Custom Query please check out our Help Page

i

CDC Laboratory Recommendations for Syphilis Testing, United States, 2024

02/08/2024
By Papp, John R. ; Park, Ina U. ; Fakile, Yetunde ; ...
http://dx.doi.org/10.15585/mmwr.rr7301a1
Source: Recommendations and Reports / February 8, 2024 / 73(1);1–32
Series: MMWR. Recommendations and Reports

[PDF-1.04 MB]

English

Details Supporting Files You May Also Like

Details:

Journal Article:

Morbidity and Mortality Weekly Report (MMWR). Recommendations and Reports
Personal Author:

Papp, John R. ; Park, Ina U. ; Fakile, Yetunde ; Pereira, Lara ; Pillay, Allan ; ... More +

Papp, John R. ; Park, Ina U. ; Fakile, Yetunde ; Pereira, Lara ; Pillay, Allan ; Bolan, Gail A. Less -
Corporate Authors:

National Center for HIV, Viral Hepatitis, STD, and TB Prevention (U.S.). Division of STD Prevention. ; University of California San Francisco. ; Task Force for Global Health.

National Center for HIV, Viral Hepatitis, STD, and TB Prevention (U.S.). Division of STD Prevention. ; University of California San Francisco. ; Task Force for Global Health. Less -
Description:

This report provides new CDC recommendations for tests that can support a diagnosis of syphilis, including serologic testing and methods for the identification of the causative agent Treponema pallidum. These comprehensive recommendations are the first published by CDC on laboratory testing for syphilis, which has traditionally been based on serologic algorithms to detect a humoral immune response to T. pallidum. These tests can be divided into nontreponemal and treponemal tests depending on whether they detect antibodies that are broadly reactive to lipoidal antigens shared by both host and T. pallidum or antibodies specific to T. pallidum, respectively. Both types of tests must be used in conjunction to help distinguish between an untreated infection or a past infection that has been successfully treated. Newer serologic tests allow for laboratory automation but must be used in an algorithm, which also can involve older manual serologic tests. Direct detection of T. pallidum continues to evolve from microscopic examination of material from lesions for visualization of T. pallidum to molecular detection of the organism. Limited point-of-care tests for syphilis are available in the United States; increased availability of point-of-care tests that are sensitive and specific could facilitate expansion of screening programs and reduce the time from test result to treatment. These recommendations are intended for use by clinical laboratory directors, laboratory staff, clinicians, and disease control personnel who must choose among the multiple available testing methods, establish standard operating procedures for collecting and processing specimens, interpret test results for laboratory reporting, and counsel and treat patients. Future revisions to these recommendations will be based on new research or technologic advancements for syphilis clinical laboratory science.
Content Notes:

Introduction -- Methods -- Updating Syphilis Serologic Laboratory Terminology -- Principles for Syphilis Diagnosis -- Recommendations for Syphilis Testing in the United States -- Opportunities for Additional Research on the Laboratory Detection of T. pallidum Infections -- References.
Subjects:

[+]

Humans Serologic Tests Syphilis/diagnosis Syphilis Serodiagnosis/methods Treponema Pallidum
Keywords:

[+]

Laboratory Recommendations Syphilis Testing
Source:

Recommendations and Reports / February 8, 2024 / 73(1);1–32
Series:

MMWR. Recommendations and Reports
Publisher:

Centers for Disease Control and Prevention
Pubmed ID:

38319847
Pubmed Central ID:

PMC10849099
Document Type:

Journal Issue
Genre:

Guideline
Place as Subject:

United States
Topic:

Syphilis
Location:

North America
Pages in Document:

1-32
Volume:

73
Issue:

1
Citation:

Papp JR, Park IU, Fakile Y, Pereira L, Pillay A, Bolan GA. CDC Laboratory Recommendations for Syphilis Testing, United States, 2024. MMWR Recomm Rep 2024;73(No. RR-1):1–32. DOI: http://dx.doi.org/10.15585/mmwr.rr7301a1.
Collection(s):

Morbidity and Mortality Weekly Report (MMWR)
Main Document Checksum:

[+]

urn:sha-512:36604848102aad9ed8e2d772a358829795e2ec64b5171b0c3377b8dedcccb7584ac745e163175007f3f057f38866eca45c2653b4e792c5f5e8f126c42ac355a8
Download URL:

https://stacks.cdc.gov/view/cdc/147800/cdc_147800_DS1.pdf
File Type:

rr7301a1.htm?s_cid=rr7301a1_w

bin

More +