Cardiac complications in thalassemia throughout the lifespan: Victories and challenges

Wood, John C.

doi:10.1111/nyas.15078

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Cardiac complications in thalassemia throughout the lifespan: Victories and challenges

12 2023
By Wood, John C.
Source: Ann N Y Acad Sci. 1530(1):64-73

Public Access Version Available on: December 01, 2024, 12:00 AM

Please check back on the date listed above.

English

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Details:

Alternative Title:

Ann N Y Acad Sci
Personal Author:

Wood, John C.
Description:

Thalassemias are among the most common hereditary diseases in the world because heterozygosity offers protection against malarial infection. Affected individuals have variable expression of alpha or beta chains that lead to their unbalanced utilization during hemoglobin formation, oxidative stress, and apoptosis of red cell precursors prior to maturation. Some individuals produce sufficient hemoglobin to survive but suffer the vascular stress imposed by chronic anemia and ineffective erythropoiesis. In other patients, mature red cell formation is insufficient, and chronic transfusions are required-suppressing anemia and ineffective erythropoiesis but at the expense of iron overload. The cardiovascular consequences of thalassemia have changed dramatically over the previous five decades because of evolving treatment practices. This review summarizes this evolution, focusing on complications and management pertinent to modern patient cohorts.
Keywords:

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Arrhythmias Beta-Thalassemia Cardiovascular Health Chelation Erythropoiesis Heart Heart Failure Hemoglobins Humans Iron Overload Longevity Pulmonary Hypertension Thalassemia
Source:

Ann N Y Acad Sci. 1530(1):64-73
Pubmed ID:

37902424
Pubmed Central ID:

PMC10841366
Document Type:

Journal Article
Funding:

1 RO1 HL075592-01A1/HL/NHLBI NIH HHSUnited States/ ; R01 HL075592/HL/NHLBI NIH HHSUnited States/ ; 1R01DK097115-01A1/DK/NIDDK NIH HHSUnited States/ ; 1 U01 DD000309-1/CC/CDC HHSUnited States/ ; R01 DK097115/DK/NIDDK NIH HHSUnited States/ ; ... More +

1 RO1 HL075592-01A1/HL/NHLBI NIH HHSUnited States/ ; R01 HL075592/HL/NHLBI NIH HHSUnited States/ ; 1R01DK097115-01A1/DK/NIDDK NIH HHSUnited States/ ; 1 U01 DD000309-1/CC/CDC HHSUnited States/ ; R01 DK097115/DK/NIDDK NIH HHSUnited States/ ; M01 RR000043/RR/NCRR NIH HHSUnited States/ ; U01 DD000309/DD/NCBDD CDC HHSUnited States/ ; UL1 TR001855/TR/NCATS NIH HHSUnited States/ Less -
Volume:

1530
Issue:

1
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha-512:6d1776f30abbccc9853c7d3561c1a598395c2a4d6184a9aee04fb0827aadc187f6292b58a22dd5a434c47583e885f334bdb84420a8bba7313537c31d0b4157b7
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