Molecular Evolution and Increasing Macrolide Resistance of Bordetella pertussis, Shanghai, China, 2016–2022

Fu, Pan; Zhou, Jinlan; Yang, Chao; Nijiati, Yaxier; Zhou, Lijun; Yan, Gangfen; Lu, Guoping; Zhai, Xiaowen; Wang, Chuanqing

doi:10.3201/eid3001.221588

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Molecular Evolution and Increasing Macrolide Resistance of Bordetella pertussis, Shanghai, China, 2016–2022

1 2024
By Fu, Pan ; Zhou, Jinlan ; Yang, Chao ; ...
http://dx.doi.org/10.3201/eid3001.221588
Source: Emerg Infect Dis. 2024; 30(1):29-38

[PDF-3.48 MB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Fu, Pan ; Zhou, Jinlan ; Yang, Chao ; Nijiati, Yaxier ; Zhou, Lijun ; ... More +

Fu, Pan ; Zhou, Jinlan ; Yang, Chao ; Nijiati, Yaxier ; Zhou, Lijun ; Yan, Gangfen ; Lu, Guoping ; Zhai, Xiaowen ; Wang, Chuanqing Less -
Description:

Resurgence and spread of macrolide-resistant Bordetella pertussis (MRBP) threaten global public health. We collected 283 B. pertussis isolates during 2016-2022 in Shanghai, China, and conducted 23S rRNA gene A2047G mutation detection, multilocus variable-number tandem-repeat analysis, and virulence genotyping analysis. We performed whole-genome sequencing on representative strains. We detected pertussis primarily in infants (0-1 years of age) before 2020 and older children (>5-10 years of age) after 2020. The major genotypes were ptxP1/prn1/fhaB3/ptxA1/ptxC1/fim2-1/fim3-1 (48.7%) and ptxP3/prn2/fhaB1/ptxA1/ptxC2/fim2-1/fim3-1 (47.7%). MRBP increased remarkably from 2016 (36.4%) to 2022 (97.2%). All MRBPs before 2020 harbored ptxP1, and 51.4% belonged to multilocus variable-number tandem-repeat analysis type (MT) 195, whereas ptxP3-MRBP increased from 0% before 2020 to 66.7% after 2020, and all belonged to MT28. MT28 ptxP3-MRBP emerged only after 2020 and replaced the resident MT195 ptxP1-MRBP, revealing that 2020 was a watershed in the transformation of MRBP.
Subjects:

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Adolescent Anti-Bacterial Agents Bordetella Pertussis Child Child, Preschool Drug Resistance, Bacterial Evolution, Molecular Humans Infant Macrolides Whooping Cough
Keywords:

[+]

Antimicrobial Resistance Bacteria China Genotype Macrolide Shanghai Vaccine-preventable Diseases
Source:

Emerg Infect Dis. 2024; 30(1):29-38
Pubmed ID:

38146984
Pubmed Central ID:

PMC10756392
Document Type:

Journal Article
Place as Subject:

China
Volume:

30
Issue:

1
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:ee3d4b6d9ffe5343e2b1f2ef4266602b9238c68e721d10e751f38136d40775ef
Download URL:

https://stacks.cdc.gov/view/cdc/140557/cdc_140557_DS1.pdf
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