Statewide Molecular Epidemiology of Mycobacterium tuberculosis Transmission in a Moderate- to Low-Incidence State: Are Contact Investigations Enough?

Cronin, Wendy A.; Golub, Jonathan E.; Lathan, Monica J.; Mukasa, Leonard N.; Hooper, Nancy; Razeq, Jafar H.; Baruch, Nancy G.; Mulcahy, Donna; Benjamin, William H.; Magder, Laurence S.; Strickland, G. Thomas; Bishai, William R.

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Statewide Molecular Epidemiology of Mycobacterium tuberculosis Transmission in a Moderate- to Low-Incidence State: Are Contact Investigations Enough?

Nov 2002
By Cronin, Wendy A. ; Golub, Jonathan E. ; Lathan, Monica J. ; ...
Source: Emerg Infect Dis. 8(11):1271-1279.

[PDF-306.51 KB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Cronin, Wendy A. ; Golub, Jonathan E. ; Lathan, Monica J. ; Mukasa, Leonard N. ; Hooper, Nancy ; ... More +

Cronin, Wendy A. ; Golub, Jonathan E. ; Lathan, Monica J. ; Mukasa, Leonard N. ; Hooper, Nancy ; Razeq, Jafar H. ; Baruch, Nancy G. ; Mulcahy, Donna ; Benjamin, William H. ; Magder, Laurence S. ; Strickland, G. Thomas ; Bishai, William R. Less -
Description:

To assess the circumstances of recent transmission of tuberculosis (TB) (progression to active disease <2 years after infection), we obtained DNA fingerprints for 1172 (99%) of 1179 Mycobacterium tuberculosis isolates collected from Maryland TB patients from 1996 to 2000. We also reviewed medical records and interviewed patients with genetically matching M. tuberculosis strains to identify epidemiologic links (cluster investigation). Traditional settings for transmission were defined as households or close relatives and friends; all other settings were considered nontraditional. Of 436 clustered patients, 115 had recently acquired TB. Cluster investigations were significantly more likely than contact investigations to identify patients who recently acquired TB in nontraditional settings (33/42 vs. 23/72, respectively; p<0.001). Transmission from a foreign-born person to a U.S.-born person was rare and occurred mainly in public settings. The time from symptom onset to diagnosis was twice as long for transmitters as for nontransmitters (16.8 vs. 8.5 weeks, respectively; p<0.01). Molecular epidemiologic studies showed that reducing diagnostic delays can prevent TB transmission in nontraditional settings, which elude contact investigations.
Subjects:

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Adolescent Adult Aged Child Child, Preschool Contact Tracing DNA Fingerprinting Female Genotype Humans Incidence Infant Male Middle Aged Molecular Epidemiology Mycobacterium Tuberculosis Polymorphism, Restriction Fragment Length Risk Factors Socioeconomic Factors Time Factors Tuberculosis
Source:

Emerg Infect Dis. 8(11):1271-1279.
Document Type:

Journal Article
Place as Subject:

Maryland
Volume:

8
Issue:

11
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:bdade3c296105df0099dbd1346649b82ede082bbe6dfbd513224d97c47d1bd6d
Download URL:

https://stacks.cdc.gov/view/cdc/14013/cdc_14013_DS1.pdf
File Type:

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	02-0261_FinalR.nxml	txt
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