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Radon and Lung Cancer in the Pooled Uranium Miners Analysis (PUMA): Highly-exposed Early Miners and All Miners
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7 2023
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Source: Occup Environ Med. 80(7):385-391
[PDF-126.08 KB]
Details:
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Alternative Title:Occup Environ Med
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Personal Author:
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Description:Objectives:
Radon is a ubiquitous occupational and environmental lung carcinogen. We aim to quantify the association between radon progeny and lung cancer mortality in the largest and most up-to-date pooled study of uranium miners.
Methods:
The Pooled Uranium Miners Analysis combines seven cohorts of male uranium miners with 7,754 lung cancer deaths and 4.3 million person-years of follow-up. Vital status and lung cancer deaths were ascertained 1946-2014. The association between cumulative radon exposure in working level months (WLM) and lung cancer was modelled as the excess relative rate (ERR) per 100 WLM using Poisson regression; variation in the association by temporal and exposure factors was examined. We also examine analyses restricted to miners first hired before 1960.
Results:
In a model that allows for variation by attained age, time since exposure, and annual exposure rate, the ERR/100 WLM was 4.68 (95% CI: 2.88, 6.96) among miners who were less than 55 years of age and were exposed in the prior 5-<15 years at annual exposure rates of <0.5 WL. This association decreased with older attained age, longer time since exposure, and higher annual exposure rate. In analyses restricted to men first hired before 1960 we observed similar patterns of association but a slightly lower estimate of the ERR per 100 WLM.
Conclusions:
This new large, pooled study confirms and supports a linear exposure-response relationship between cumulative radon exposure and lung cancer mortality which is jointly modified by temporal and exposure factors.
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Pubmed ID:37164624
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Pubmed Central ID:PMC10369304
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Funding:
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Volume:80
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Issue:7
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