Preexisting Heterotypic Ligand-blocking Antibody Does Not Protect Against Genogroup II Norovirus Episodes in Young Children

Becker-Dreps, Sylvia; Brewer-Jensen, Paul D.; González, Fredman; Reyes, Yaoska; Mallory, Michael L.; Gutiérrez, Lester; Vielot, Nadja A.; Diez-Valcarce, Marta; Vinjé, Jan; Baric, Ralph S.; Lindesmith, Lisa C.; Bucardo, Filemon

doi:10.1093/jpids/piac063

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Preexisting Heterotypic Ligand-blocking Antibody Does Not Protect Against Genogroup II Norovirus Episodes in Young Children

7 18 2022
By Becker-Dreps, Sylvia ; Brewer-Jensen, Paul D. ; González, Fredman ; ...
http://dx.doi.org/10.1093/jpids/piac063
Source: J Pediatric Infect Dis Soc. 11(10):459-462

[PDF-324.64 KB]

English

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Details:

Alternative Title:

J Pediatric Infect Dis Soc
Personal Author:

Becker-Dreps, Sylvia ; Brewer-Jensen, Paul D. ; González, Fredman ; Reyes, Yaoska ; Mallory, Michael L. ; ... More +

Becker-Dreps, Sylvia ; Brewer-Jensen, Paul D. ; González, Fredman ; Reyes, Yaoska ; Mallory, Michael L. ; Gutiérrez, Lester ; Vielot, Nadja A. ; Diez-Valcarce, Marta ; Vinjé, Jan ; Baric, Ralph S. ; Lindesmith, Lisa C. ; Bucardo, Filemon Less -
Description:

A birth cohort design was used to understand whether heterotypic ligand-blocking norovirus antibodies provide cross-protection within the GII genogroup. We found that almost one-half of children who experienced a norovirus GII episode had preexisting antibodies heterotypic to the infecting genotype; therefore, these antibodies did not provide cross-protection.
Subjects:

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Caliciviridae Infections Child Child, Preschool Feces Gastroenteritis Genotype Humans Infant Ligands Norovirus
Keywords:

[+]

Children Diarrhea Gastroenteritis Immunity Nicaragua Norovirus
Source:

J Pediatric Infect Dis Soc. 11(10):459-462
Pubmed ID:

35849117
Pubmed Central ID:

PMC9595053
Document Type:

Journal Article
Funding:

K24 AI141744/AI/NIAID NIH HHSUnited States/ ; D43TW010923/TW/FIC NIH HHSUnited States/ ; R01 AI127845/AI/NIAID NIH HHSUnited States/ ; R01 AI148260/AI/NIAID NIH HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; ... More +

K24 AI141744/AI/NIAID NIH HHSUnited States/ ; D43TW010923/TW/FIC NIH HHSUnited States/ ; R01 AI127845/AI/NIAID NIH HHSUnited States/ ; R01 AI148260/AI/NIAID NIH HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; D43 TW010923/TW/FIC NIH HHSUnited States/ Less -
Volume:

11
Issue:

10
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:b157a77129f3ebbdd9468c06778410790a3ad784c30499550b3edb33356e0eef
Download URL:

https://stacks.cdc.gov/view/cdc/121969/cdc_121969_DS1.pdf
File Type:

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