Detecting Mycobacterium tuberculosis Infection in Children Migrating to Australia

Laemmle-Ruff, Ingrid; Graham, Stephen M.; Williams, Bridget; Horyniak, Danielle; Majumdar, Suman S.; Paxton, Georgia A.; Soares Caplice, Lila V.; Hellard, Margaret E.; Trauer, James M.

doi:10.3201/eid2809.212426

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Detecting Mycobacterium tuberculosis Infection in Children Migrating to Australia

9 2022
By Laemmle-Ruff, Ingrid ; Graham, Stephen M. ; Williams, Bridget ; ...
http://dx.doi.org/10.3201/eid2809.212426
Source: Emerg Infect Dis. 2022; 28(9):1833-1841

[PDF-826.19 KB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Laemmle-Ruff, Ingrid ; Graham, Stephen M. ; Williams, Bridget ; Horyniak, Danielle ; Majumdar, Suman S. ; ... More +

Laemmle-Ruff, Ingrid ; Graham, Stephen M. ; Williams, Bridget ; Horyniak, Danielle ; Majumdar, Suman S. ; Paxton, Georgia A. ; Soares Caplice, Lila V. ; Hellard, Margaret E. ; Trauer, James M. Less -
Description:

In 2015, Australia updated premigration screening for tuberculosis (TB) disease in children 2-10 years of age to include testing for infection with Mycobacterium tuberculosis and enable detection of latent TB infection (LTBI). We analyzed TB screening results in children <15 years of age during November 2015-June 2017. We found 45,060 child applicants were tested with interferon-gamma release assay (IGRA) (57.7% of tests) or tuberculin skin test (TST) (42.3% of tests). A total of 21 cases of TB were diagnosed: 4 without IGRA or TST, 10 with positive IGRA or TST, and 7 with negative results. LTBI was detected in 3.3% (1,473/44,709) of children, for 30 applicants screened per LTBI case detected. LTBI-associated factors included increasing age, TB contact, origin from a higher TB prevalence region, and testing by TST. Detection of TB and LTBI benefit children, but the updated screening program's effect on TB in Australia is likely to be limited.
Subjects:

[+]

Child Humans Interferon-Gamma Release Tests Latent Tuberculosis Mass Screening Mycobacterium Tuberculosis Tuberculin Test
Source:

Emerg Infect Dis. 2022; 28(9):1833-1841
Pubmed ID:

35997353
Pubmed Central ID:

PMC9423895
Document Type:

Journal Article
Place as Subject:

Australia
Volume:

28
Issue:

9
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:1cdee6e4095804d03dec02bd6891a4036d5bdea916476558b25a58e3693ec891
Download URL:

https://stacks.cdc.gov/view/cdc/121030/cdc_121030_DS1.pdf
File Type:

21-2426.nxml

xml

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